MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202617069476 A) filed by Treeline Biosciences, Inc. on June 03, 2026, for Tetrahydroisoquinoline Heterobifunctional Bcl-X L Degraders.
Inventors include Horn, Evan J.; Hansen, Joshua D.; Alexander, Matthew D.; Huang, Fei; Nagy, Mark A. Number; and Zahara, Adam Jamil.
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: This disclosure provides compounds of Formula (I) (e.g., Formula (I-1) (e.g., (I-a1), (I-b1), (I-b3), (I-c1), (I-d1), (I-e1), (I-e3), (I-f1), (I-g1), (I-g3), (I-h1), (I-i1), or (I-i3)) or Formula (I-2) (e.g., (I-a2), (I-b2), (I-b4), (I-c2), (I-d2), (I-e2), (I-e4), (I-f2), (I-g2), (I-g4), (I- h2), or (I-i2))), Formula (II) (e.g., Formula (II-a1) or (II-a2)), or Formula (A), or a pharmaceutically acceptable salt thereof, that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions comprising the compounds, or pharmaceutically acceptable salts thereof, provided herein as well as methods of using and making the same.
Disclaimer: Curated by HT Syndication.
