MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202617069474 A) filed by Treeline Biosciences, Inc. on June 03, 2026, for Tetrahydroisoquinoline Heterobifunctional Bcl-X L Degraders.
Inventors include Horn, Evan J.; Hansen, Joshua D.; Alexander, Matthew D.; Huang, Fei Number; and Nagy, Mark A..
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: This disclosure provides compounds of Formula (I) (e.g., Formula (I-a), (I-b), (I-b1), (I-b2), (I-b3), or (I-b4)), or a pharmaceutically acceptable salt thereof that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions comprising the compounds of Formula (I) (e.g., Formula (I-a), (I-b), (I-b1), (I-b2), (I-b3), or (I-b4)), or pharmaceutically acceptable salts thereof, as well as methods of using and making the same.
Disclaimer: Curated by HT Syndication.
