MUMBAI, India, Aug. 31 -- Intellectual Property India has published a patent application (202641101458 A) filed by Mr. Hari Krishna Marrapu; Dr. Naveen S Kotur; Dr. Amarendranath Choudhury; Prof. Dr. S China Venkateswarlu; Dr. Sayyed Johar; Mrs. Pratika R K; Ms. Earli Manemma; Dr. Rizwana; Dr. C. Priya; and Dr. K. Prabhu Chandran on August 21, 2026, for System And Method For Computer-Assisted Early Imaging Biomarker Detection And Prognostic Assessment Of Neurodegenerative Conditions.
Inventors include Mr. Hari Krishna Marrapu; Dr. Naveen S Kotur; Dr. Amarendranath Choudhury; Prof. Dr. S China Venkateswarlu; Dr. Sayyed Johar; Mrs. Pratika R K; Ms. Earli Manemma; Dr. Rizwana; Dr. C. Priya; and Dr. K. Prabhu Chandran.
The application for the patent was published on August 28, 2026, under issue no. 35/2026.
Abstract: 075] The present invention discloses a system and method for computer-assisted detection and longitudinal evaluation of imaging biomarkers in MRI and/or CT scan data associated with neurodegenerative conditions. Volumetric image data are standardized to compensate for spatial, image-value, resolution, and acquisition-domain variations. Anatomical regions are identified, and a multi- scale deep feature extraction network extracts local, regional, and global imaging features. A biomarker correlation engine processes relationships between anatomically related regions to generate a topology-aware quantitative biomarker representation. Temporally separated scans may be anatomy-constrained registered and compared to generate a longitudinal biomarker-change vector while reducing scanner-dependent variation. An uncertainty estimation engine determines confidence values using image-quality and processing-reliability information. A structured output comprising quantitative biomarker measurements, anatomical location information, longitudinal changes, and associated confidence values is generated for computer-assisted professional assessment of structural changes relevant to neurodegenerative conditions. Accompanied Drawing [FIGS. 1-2]
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