MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202641096087 A) filed by Dr. Prasad Pinnoju, Assistant Professor Department Of Chemistry, Jntuh University College Of Engineering, Mahabubabad.; Dr. M. Sarasija, Assistant Professor Department Of Chemistry, Satavahana University, Karimnagar.; Prof. U. Umesh Kumar, Senior Professor Department Of Chemistry, Osmania University.; and Madavi Ramesh, Research Scholar Department Of Chemistry on August 08, 2026, for Synthesis And Screening Of 1-Methylisatin-Linked 1,2,3-Triazoles As Vegfr-2 Inhibitors And Their Molecular Docking Studies.
Inventors include Dr. Prasad Pinnoju, Assistant Professor Department Of Chemistry; Dr. M. Sarasija, Assistant Professor Department Of Chemistry; Prof. U. Umesh Kumar, Senior Professor Department Of Chemistry; and Madavi Ramesh, Research Scholar Department Of Chemistry.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: Abstract The pharmacophore hybridization strategy is an effective method to reduce side effects and overcome drug resistance by utilizing multiple mechanisms of action. In this context, we have applied this approach to synthesize isatin-1,2,3-triazole hybrids (Va–Vn) as potential in vitro VEGFR-2 inhibitors. Methods: Copper(I)- catalyzed azide-alkyne cycloaddition (CuAAC) was employed for the synthesis of isatin-1,2,3-triazole hybrids (Va–Vn). The compounds were screened for in vitro anticancer activity against MCF-7 and HepG2 cell lines using the MTT assay, with sunitinib as the reference drug. Additionally, in vitro tyrosine kinase VEGFR-2 inhibi-tion assays and molecular docking studies were conducted for four potent compounds.
Disclaimer: Curated by HT Syndication.
