MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202611060789 A) filed by M. J. P. Rohilkhand University, Bareilly on May 13, 2026, for Synthesis And Computational Evaluation Of Coumarin Based Silver And Copper Metal Complexes For Therapeutic Applications.
Inventors include Shweta Gupta; Pawan Kumar Gupta; Shreya Gupta; Dr. Shiv Dev Singh; Dr. Shashi Bhooshan Tiwari; Shaily Saini; Ayushi Kaushik; Aadya Misra; and Navi Hasan.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention relates to synthesis and in silico evaluation of coumarin-based silver(I) and copper(II) metal complexes for therapeutic applications. The invention provides a reproducible synthesis process using a coumarin precursor compound (10), resorcinol substrate unit (11), ethyl acetoacetate reagent system (12), acid catalyzed condensation reactor (13), and heterocyclic ligand modules including imidazole ligand module (22), pyrazole ligand module (23), and piperazine ligand module (24). Metal complex formation is achieved using copper salt reagent system (40) and silver salt reagent system (50). The synthesized complexes are purified using filtration and purification assembly (34) and characterized using UV-visible spectroscopic analyzer (60), infrared spectroscopic analyzer (61), nuclear magnetic resonance system (62), gas chromatography mass spectrometer (63), and X-ray diffraction analyzer (64). Computational evaluation using DFT computational processing module (70) and molecular docking platform (80) demonstrates significant binding affinity against Alzheimer’s disease and bacterial infection related proteinu ptarpogrtinets, g s pharmaceutical and therapeutic applicability.
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