MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641053936 A) filed by Dr Uppuluri Spandana on April 28, 2026, for Synergestic Effect Of Bacopa Monnieri With Metformin In Stz Induced Diabetes In Sprague Drawley Rats (sd Rats).
Inventors include Dr Uppuluri Spandana; Illuri Supriya; Bandi. Sanjana; D. Joyce Kamal; Kolli. Bharath; Mendu. Dora Babu; N. Indu; N. Jahnavi; Nedunuri. Koushik Teja; Shaik. Saania; and V. Venkata Sai Padmini.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: ABSTRACT: The present invention relates to a synergistic antidiabetic composition comprising an extract of Bacopa monnieri in combination with Metformin for the effective management of diabetes mellitus. The invention provides a novel herb-drug therapeutic approach that enhances glycemic control through complementary mechanisms, including improved insulin sensitivity, reduced hepatic glucose production, and attenuation of oxidative stress. The composition is evaluated using a streptozotocin-induced diabetes model in Sprague Dawley rat, demonstrating significant . reduction in blood glucose levels, improved glucose tolerance, and favorable modulation of biochemical and oxidative stress parameters. The combination further exhibits protective effects on pancreatic p-cells. Additionally, the invention enables dose reduction of metformin, thereby minimizing associated adverse effects. The composition can be formulated into various oral dosage forms and offers a safe, effective, and improved strategy for diabetes management
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