MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611106805 A) filed by Panipat Institute Of Engineering And Technology Piet on September 04, 2026, for Sustained Release Pharmaceutical Tablet Composition Of Ciprofloxacin Hydrochloride And Method For Preparation Thereof.
Inventors include Dr. Ajay Malik; Dr. Parveen Kumar Goyal; Dr. Vijay Sharma; and Dr. Navneet Verma.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: [052] The present invention relates to a sustained release pharmaceutical tablet composition of ciprofloxacin hydrochloride and a method for preparation thereof. The composition comprises ciprofloxacin hydrochloride, chitosan and at least one anionic polymer capable of forming an in situ polyelectrolyte complex with chitosan upon exposure to an aqueous acidic medium. The anionic polymer may comprise sodium starch glycolate, xanthan gum, or a combination thereof. In exemplary embodiments, a 1% w/v chitosan solution in 1% acetic acid is used as a granulating binder, and the resulting granules are dried, sized, lubricated and compressed into tablets. Ionic association between chitosan and the anionic polymer produces a hydrated release-retarding matrix that reduces burst release and regulates drug release by diffusion, swelling and erosion. Evaluated formulations comprising sodium starch glycolate alone or together with xanthan gum sustained ciprofloxacin hydrochloride release for up to about 12 hours and exhibited release behaviour consistent with formation of the polyelectrolyte complex. Accompanied Drawing [FIGS. 1-4]
Disclaimer: Curated by HT Syndication.
