MUMBAI, India, June 22 -- Intellectual Property India has published a patent application (202641070383 A) filed by Vellore Institute Of Technology on June 05, 2026, for Sugarcane Bagasse-Mediated Non-Genetic Activation Of Isoprenoid Biosynthetic Pathway In Streptomyces Sp. Vitgv156 (mcc 4965) For Enhanced Squalene Production.
Inventors include J Godwin Christopher; and Dr. P. Veilumuthu.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: Sugarcane Bagasse-Mediated Non-Genetic Activation of Isoprenoid Biosynthetic Pathway in Streptomyces sp. VITGV156 (MCC 4965) for Enhanced Squalene Production. The present invention relates to a method for enhancing squalene production using a non-genetically modified microbial system. The method comprises cultivating Streptomyces sp. VITGV156 in a fermentation medium comprising sugarcane bagasse, wherein the substrate induces activation of isoprenoid biosynthetic pathways associated with squalene synthesis. The activation occurs through substrate-induced metabolic effects without genetic modification of the microorganism. The method results in increased squalene production and enables utilization of agro-industrial waste as a functional substrate. The invention provides a sustainable and scalable approach for microbial production of squalene and distinguishes over prior art by employing strain-specific, non-GMO pathway activation using sugarcane bagasse. (FIG. 1)
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