MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202611074305 A) filed by K. R. Mangalam University on June 15, 2026, for Redox-Responsive Self-Neutralizing Metal Oxide Nanoparticles With Built-In Toxicity Regulation Mechanism.
Inventors include Dr. Mahipal Singh Sankhla; Dr. Baljeet Yadav; Prof. Dr. Garima Awasthi; and Prof. Dr. Kumud Kant Awasthi.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: The present invention relates to nanomaterials with environment-dependent self-regulation. Conventional metal oxide nanoparticles generate ROS and metal ions uncontrollably, causing excessive toxicity in healthy tissues. The invention provides a redox-responsive nanoparticle composition (100) comprising a metal oxide core (202) of zinc oxide or titanium dioxide, a redox-responsive ligand layer (204) with thiol groups or disulfide bonds that undergo conformational change under oxidative conditions, and integrated self-neutralizing antioxidant components (206). The nanoparticles exhibit suppressed ROS and toxicity under normal reducing conditions but activate and generate ROS under high-oxidative-stress conditions, with automatic ROS scavenging by the antioxidant component to prevent uncontrolled damage. A method (300) of preparation and a non-therapeutic method (400) of modulating nanoparticle reactivity are provided. The toxicity is self-regulating and tunable, representing a qualitatively new functional property.
Disclaimer: Curated by HT Syndication.
