MUMBAI, India, Aug. 31 -- Intellectual Property India has published a patent application (202647099677 A) filed by Revatis S. A. on August 18, 2026, for Process For The Preparation Of An Extracellular Vesicle Composition, Extracellular Vesicle Composition And Use Thereof.
Inventors include Serteyn, Didier; Ceusters, Justine; Duysens, Julien; Graide, Hlne; and Sandersen, Charlotte.
The application for the patent was published on August 28, 2026, under issue no. 35/2026.
Abstract: The present invention provides a novel process for the preparation of a extracellular vesicle (EV) comprising composition, the process comprising the steps of (i) growing stem cells in a culture medium; possibly dissociating the stem cells obtained in step (i) from their support and possibly separating the stem cells from the medium used in step (i); (ii) rinsing the obtained stem cells in an isotonic electrolyte solution; (iii) subjecting the cell containing isotonic electrolyte solution to a gentle mechanical stimulation and separating the cells from the medium and retaining the medium, the separated cells being discarded; and (iv) possibly separating remaining undesirable components, cells and cell debris from the medium of interest retained at step (iii) The discarded cells may be used in further culture cycles and/or for other applications. The EV comprising composition of the invention further comprises cell- originating immunomodulating proteins and miRNAs and may be used in the treatment of disorders selected from Systemic Inflammation Response Syndrome (SIRS); Acute Respiratory Distress Syndrome (ARDS), acute or degenerative conditions of several organs as liver, lung, heart, uterus, brain, eye, skin, bone, tendon and cartilage, in mammalian subjects.
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