Intellectual Property India Publishes Patent Application for Preparation Of Bridged Pentacyclic Imidazole Derivatives As Modulators Of Tnf Activity, Intermeditates And Their Preparation

MUMBAI, India, Aug. 12 -- Intellectual Property India has published a patent application (202617053652 A) filed by Sanofi; and Ucb Biopharma Srl on April 27, 2026, for Preparation Of Bridged Pentacyclic Imidazole Derivatives As Modulators Of Tnf Activity, Intermeditates And Their Preparation.

Inventors include Barthes, Matthieu; Baylon, Christophe; Greciet, Hlne; Cerfontaine, Patrick; Gerard, Julien; and Petit, Sylvain.

The application for the patent was published on August 07, 2026, under issue no. 32/2026.

Abstract: Provided herein is a method of preparing a compound of Formula (I): i.e. (7R,14R)-11-[2-(1-aminocyclobutyl)pyrimidin-5-yl]-1-(difluoromethoxy)-6-methyl-6,7- dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one. Also described are intermediates, methods of manufacturing intermediates, and a crystalline form of an intermediate.

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