MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641069045 A) filed by Dr. Guhanathan. S; Nikila. S; Harini. S; and Dr. Jmran Predhanekar on June 02, 2026, for Pinacol Containing Tetra Component Biodegradable Hydrogels As Potent Antifungal Agents.
Inventors include Dr. Guhanathan. S Supervisor; Nikila. S; Harini. S; and Dr. Jmran Predhanekar.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: Hydrogels are three-dimensional, hydrophilic polymeric networks that absorb and retain enonnous amounts of water or biological fluids without disintegrating in their medium. In this study, a pH-sensitive tetra component hydrogel was synthesized from citric acid, I ,6- Hexanediol, Pinacol and 2- Furoic acid (CHPIF) by employing an eco-friendly melt condensation technique without the use of any external crosslinking agents. The presence of functional groups in the synthesized hydrogels was confinned hy various spectral investigations FT-IR and 1H and 13C NMR. Its thermal stability and morphological characteristics have been studied by TGA and SEM analysis. The equilibrium swelling studies of pinacol-based hydrogels was examined at various pH levels (2.0, 4.0, 7.0, 9.0, and 11.0). The hydrogels exhibited pH- sensitive swelling behaviour, demonstrating greater swelling in basic media than acidic. The antibacterial studies were evaluated against two pathogenic microorganism namely B.subtilis and E.coli by agar well diffusion method. Similarly antifungal activity evaluated by agar well diffusion technique against C.albicans and A. flavus. The biodegradability of the hydrogel was studied through soil burial method, which provides a realistic evaluation of environmental degradation under natural conditions. OFT provides insights into electronic structure and interaction mechanisms, perhaps, the molecular clocking explains binding behaviour. Notably, strong interactions and a higher clocking score with cytochrome P450 of candida albicans (STZI), was obtained. It acts as a key enzyme involved in Ergosterol biosynthesis, indicative of effective enzyme inhibition and increased antifungal potential. ADMET analysis further examines stability, transport, and safety-relevant features, supporting rational design and accurate perfonnance prediction. This invention probes into the structural characteristics of the biopolymeric hydro gels and explores its biological activities especially antibacterial and antifungal.
Disclaimer: Curated by HT Syndication.
