MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641075033 A) filed by Vani Mamillapalli; and Vijaya Institute Of Pharmaceutical Sciences For Women on June 17, 2026, for Phytoconstituents And Bioactivities Of Tephrosia Villosa Roots For In Vitro Antioxidant Capacity And A-Glucosidase Inhibition Via Molecular Docking Approaches.
Inventors include Vani Mamillapalli; Sukanya Basinikonda; Parvathi Katari; Eswari Guntamukkala; Harika Gajjala; and Beaulah Shalemu Rani Domathoti.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: ABSTRACT [0041] Medicinal plants always are of utmost prefered in various systems of medicine for the treatment they offer with least side effects and less financial burden. Diabetes mellitus is a chronic metabolic disorder affecting millions without prominent treatment. The current student was planned to evaluate alpha-glucosidase inhibition of Tephrosia villosa root extract, fractions, and isolated compound via in vitro, in silico approaches. The extract and fractions were standardised by FTIR finger print analysis. GC-MS analysis of biologically active hydroethanolic extract revealed 28 compounds, out of which 6 compounds were screened through Protox, out of which 3 compounds sent for docking analysis offered favourable binding for 2 components namely 2,4-thiazolidinedione and 1,5-diphenyl-2H-1,2,4–triazoline-3- thione. Moreover, the isolated Trilaurin, also was docked and showed prominent binding effect. The study also analysed anti oxidant potential through DPPH and ABTS assays followed by estimation of TPC and TFC. The enzyme kinetic studies showed competitive binding affinity with lower Ki values. The study offered a total of three antidiabetic compounds which can be investigated keenly for in vivo toxicological and pharmacological screening after isolation or synthesis.
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