MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611111617 A) filed by Mr. Raj Kumar Singh Bharti; Mr. Ajay Sharma; Mr. Krishna Kumar; Mr. Dharmveer Singh; Ms. Kanchan Yadav; Mr. Yogesh Kumar; Mr. Anoj Kumar; and Mr. Anil Kumar on September 17, 2026, for Phytochemical And Pharmacological Evaluation Of Anti-Ulcer Activity Of Carica Papaya Leaf Extracts In Experimental Animals.
Inventors include Mr. Raj Kumar Singh Bharti; Mr. Ajay Sharma; Mr. Krishna Kumar; Mr. Dharmveer Singh; Ms. Kanchan Yadav; Mr. Yogesh Kumar; Mr. Anoj Kumar; and Mr. Anil Kumar.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to a gastroprotective pharmaceutical composition comprising a chloroform extract of Carica papaya leaves obtained by Soxhlet extraction, enriched in alkaloids, flavonoids, tannins, saponins, glycosides and phenolic compounds, and its therapeutic application for prevention and treatment of gastric ulcers. The composition demonstrates significant dose-dependent gastroprotective activity against ethanol-induced gastric ulceration in a rat model. At 400 mg/kg oral dose, the extract achieves 67.9 percent inhibition of ulceration, reduces ulcer index to 2.95 and elevates gastric pH to 4.85, approaching the efficacy of ranitidine. The extract possesses an LD50 exceeding 2000 mg/kg, confirming safety. Histopathological evaluation confirms preservation of gastric mucosal architecture. The invention provides a safe, natural, cost-effective and biocompatible alternative to synthetic anti-ulcer drugs for human and veterinary use.
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