MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202621096122 A) filed by Dr. Thenmozhi. B. R; Dr. Chandulal D. Dhalkari; Dr. Maya S. Indurkar; Dr. Ashokkumar Bhansali; Dr. Hiroj Bagde; Dr. Iyyappan. R; Dr. Pawan Hargunani; Dr. Shubham Pande; Dr. Madhu G. Varma; Dr. Vaidehi Singh; Dr. Soundarya Soundararajan; and Dr. Bhagyashree Bothikar on August 08, 2026, for Pathology-Responsive Magnesium-Hyaluronic Acid Bioadhesive Hydrogel For Periodontal Regeneration.
Inventors include Dr. Thenmozhi. B. R; Dr. Chandulal D. Dhalkari; Dr. Maya S. Indurkar; Dr. Ashokkumar Bhansali; Dr. Hiroj Bagde; Dr. Iyyappan. R; Dr. Pawan Hargunani; Dr. Shubham Pande; Dr. Madhu G. Varma; Dr. Vaidehi Singh; Dr. Soundarya Soundararajan; and Dr. Bhagyashree Bothikar.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: An injectable dual-component hydrogel (100) comprises a hyaluronic-acid precursor (110), polydopamine-coated magnesium peroxide particles (120), an acid- accelerated crosslinking system (130), matrix-metalloproteinase-cleavable links (140), and a peroxide-converting catalyst. Mixing through a dual-syringe applicator (200) causes in situ gelation within a periodontal pocket and catechol-mediated adhesion to dentin, cementum and collagen. The polydopamine shell controls water ingress, while the catalyst limits reactive-peroxide accumulation and generates an early oxygen phase. Magnesium ions are retained by the polymer network and released thereafter, followed by controlled scaffold remodeling. The hydrogel is configured to support biofilm disruption, hypoxia reduction, macrophage phenotype modulation, endogenous periodontal-ligament stem-cell recruitment, angiogenesis, collagen organization, cementogenesis, periodontal-ligament formation and alveolar- bone regeneration. Optional radiopaque, color-indicating, self-healing, thermoresponsive, swelling, near-infrared-responsive and therapeutic-payload embodiments are provided.
Disclaimer: Curated by HT Syndication.
