MUMBAI, India, June 26 -- Intellectual Property India has published a patent application (202641071564 A) filed by B. Dharani Priya on June 09, 2026, for Patent For Development And Evaluation Of Ethosomal Gel Containing Nicorandil For Sustained Anti-Anginal Effect.
Inventors include Chockalingam. P. L; Sneha. S; Subi Shankar. K; Sudhan. R; Varrun Sree Ram. K; Kanimozhi. M; and Naresh Kumar. S.
The application for the patent was published on June 19, 2026, under issue no. 25/2026.
Abstract: Abstract: The present invention relates to a nicorandil-loaded ethosomal gel for transdermal delivery in the management of angina pectoris. Nicorandil ethosomes were prepared using phospholipids and ethanol by the cold method and incorporated into a Carbopol gel base. The optimized formulation showed suitable vesicle size, high entrapment efficiency, acceptable pH, viscosity, spreadability, and uniform drug content. FTIR studies confirmed the compatibility of nicorandil with the selected excipients. The formulation exhibited sustained and controlled drug release for up to 360 minutes, demonstrating improved drug retention and release characteristics. The ethosomal carrier system enhances skin permeation by improving the penetration of nicorandil across the stratum corneum. The developed transdermal gel may reduce fluctuations in plasma drug concentration, improve patient compliance, and minimize the frequency of administration. The invention provides a promising alternative to conventional oral dosage forms for the effective and prolonged management of angina pectoris.
Disclaimer: Curated by HT Syndication.
