MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202611057874 A) filed by Panipat Institute Of Engineering And Technology Piet on May 06, 2026, for Paracetamol Sustained-Release Tablets Using In-Situ Chitosan–sodium Starch Glycolate Polyelectrolyte Complex.
Inventors include Dr. Ajay Malik; and Dr. Parveen Kumar Goyal.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention relates to sustained-release oral tablets of paracetamol using in-situ polyelectrolyte complex (PEC) formation. The tablet comprises paracetamol and a PEC-forming polymer pair including chitosan (cationic) and sodium starch glycolate (anionic). A chitosan binder solution is prepared as about 1% w/v in about 1% acetic acid, cooled to about 4°C and neutralized using sodium bicarbonate, and used for wet granulation of paracetamol with sodium starch glycolate and excipients, followed by sieving, drying, lubrication and compression. On exposure to acidic medium (about pH 1.5), chitosan and sodium starch glycolate form a dense PEC gel barrier that limits burst release and sustains drug diffusion. Dissolution testing using staged media (pH 1.5 for 2 h, pH 6.8 for 8 h, pH 7.5 for 2 h) demonstrates sustained release up to about 12 hours. The tablets improve dosing convenience and patient compliance. (Accompanied Figure No. 1)
Disclaimer: Curated by HT Syndication.
