MUMBAI, India, June 19 -- Intellectual Property India has published a patent application (202617056529 A) filed by Bit Bio Limited on May 04, 2026, for Novel Method To Modulate Expression Of An Endogenous Gene In A Somatic Cell.

Inventors include Kotter, Mark; Salic, Sejla; Metzakopian, Emmanouil; and Papai, Nora.

The application for the patent was published on June 05, 2026, under issue no. 23/2026.

Abstract: The invention relates to a method of modulating the expression of an endogenous gene in a somatic cell derived from an induced pluripotent stem cell (iPSC), comprising differentiating an engineered iPSC capable of stable or inducible expression of a CRISPR-related protein into a somatic cell prior to introduction of a guide RNA (gRNA) sequence. The invention also relates to the engineered iPSC, cells obtained by the method and uses thereof.

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