MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202611099167 A) filed by Dr. Harpreet Singh; Dr. Rekha Tarasingh Rajput; Lakshya Thakur; Digvijaya Saini; and Ajay Dixit on August 17, 2026, for Novel Herbal Nanoemulsion Pharmaceutical Composition For Targeted Anti-Inflammatory Therapy.
Inventors include Dr. Harpreet Singh; Dr. Rekha Tarasingh Rajput; Lakshya Thakur; Digvijaya Saini; and Ajay Dixit.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: The present invention relates to a novel oil-in-water herbal nanoemulsion pharmaceutical composition for targeted anti-inflammatory therapy comprising curcumin at 0.5 to 3% w/w, Boswellia serrata extract standardized to 65% boswellic acids at 0.5 to 2% w/w, medium-chain triglyceride oil phase, Tween 80 and Span 80 as surfactants, and a folate-polyethylene glycol-distearoyl phosphoethanolamine conjugate as targeting ligand. The nanoemulsion exhibits globule size of 50 to 95 nanometers, polydispersity index below 0.25, encapsulation efficiency above 95%, and selectively targets folate receptor-beta on activated macrophages at inflammatory sites. In preclinical studies, the composition demonstrated 4.3-fold enhanced macrophage uptake, 82% reduction in tumor necrosis factor-alpha, and 71.8% inhibition of carrageenan-induced paw edema in rats, exceeding standard diclofenac. The formulation maintains stability over 12 months and offers a safe, efficacious therapeutic option for rheumatoid arthritis, inflammatory bowel disease, and psoriasis.
Disclaimer: Curated by HT Syndication.
