MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202548097826 A) filed by Genomatica, Inc. on October 10, 2025, for Non-Natural Microbial Organisms With Improved Energetic Efficiency.
Inventors include Pharkya, Priti; Burgard, Anthony, P.; and Nunez Van Name, Eric Roland.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: ABSTRACT “NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY” The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA or oxaloacetate and acetyl-CoA. Embodiments of the invention include microbial organisms having a pathway to acetyl-CoA and oxaloacetate that includes phosphoketolase (a PK pathway). The organisms also have either (i) a genetic modification that enhances the activity of the non-phosphotransferase system (nonPTS) for sugar uptake and/or (ii) a genetic modification(s) to the organism’s electron transport chain (ETC) that enhances efficiency of ATP production, that enhances availability of reducing equivalents or both. The microbial organisms can optionally include (iii) a genetic modification that maintains, attenuates, or eliminates the activity of a phosphotransferase system (PTS) for sugar uptake. The enhanced carbon flux through acetyl-CoA and oxaloacetate can be used for production of a bioderived compound, and the microbial organisms can further include a pathway capable of producing the bioderived compound
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