MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202611099470 A) filed by Nims University Rajasthan, Jaipur on August 18, 2026, for Nanoparticle System And Method For Targeted Drug Delivery.
Inventors include Shatakshi Kumari; and Dr. Ashutosh Tripathi.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: A microbiome-responsive drug delivery system (100) for localized and on-demand delivery of active agents at sites of microbial dysbiosis. The system (100) comprises a nanoparticle core matrix (101) having a particle size between 50 nm and 500 nm, an active payload (102) encapsulated within the nanoparticle core matrix (101), a responsive outer coating (103), a sensor element (104) configured to selectively recognize quorum-sensing molecules secreted by pathogenic microorganisms, a cleavable linker (105), and a microbiota-preservation mechanism. Upon recognition of the quorum-sensing molecules, the sensor element (104) activates cleavage or structural alteration of the cleavable linker (105), thereby disrupting the responsive outer coating and releasing the active payload in a localized manner. The system may further comprise a biofilm-responsive component and skin-barrier restoration agents. The invention provides targeted drug release, preservation of beneficial skin microbiota, improved bioavailability, enhanced therapeutic efficacy, and reduced adverse effects for treatment of microbial dysbiosis-associated skin disorders.
Disclaimer: Curated by HT Syndication.
