MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202411103999 A) filed by Lovely Professional University on December 28, 2024, for Nanoemulsion Formulation For Enhanced Bioavailability Of Fisetin And Hesperidin.
Inventors include Dr. Rajan Kumar; and Dr. Sachin Kumar Singh.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: The present invention relates to a nanoemulsion formulation designed to enhance the bioavailability of fisetin and hesperidin, which are active pharmaceutical ingredients (APIs). The formulation comprises an oil phase, which includes medium-chain triglycerides (MCT) or soybean oil for dissolving the APIs, a surfactant such as Tween 80 to reduce interfacial tension, and a co-surfactant like propylene glycol to enhance stability. The aqueous phase serves as the continuous phase for dispersing the oil droplets, with the nanoemulsion characterized by droplet sizes ranging from 20 to 200 nm. The formulation is developed using a Quality by Design (QbD) approach, optimizing Critical Quality Attributes (CQAs) such as droplet size, zeta potential, drug release profile, and stability. The invention involves preparing a nanoemulsion using high-shear homogenization or ultrasonication, with process parameters optimized using Design of Experiments (DoE) tools. It falls within the pharmaceutical formulations field, aimed at improving bioactive compound delivery and efficacy
Disclaimer: Curated by HT Syndication.
