MUMBAI, India, Aug. 31 -- Intellectual Property India has published a patent application (202541015752 A) filed by Yenepoya Deemed To Be University on February 22, 2025, for Ms-Based Assays To Quantify A Panel Of Targeted Serum Protein Biomarkers For Detecting Colorectal Cancer.
Inventors include Dr. T. S. Keshava Prasad; Ms. Akhila B. Rai; Dr. Jalaluddin Akbar K C; Dr. M. Vijayakumar; and Dr. Rohan Shetty.
The application for the patent was published on August 28, 2026, under issue no. 35/2026.
Abstract: ABSTRACT MS-BASED ASSAYS TO QUANTIFY A PANEL OF TARGETED SERUM PROTEIN BIOMARKERS FOR DETECTING COLORECTAL CANCER The present disclosure relates to a mass spectrometry-based method for identification and 5 quantification of colorectal cancer-specific protein biomarkers; a composition of proteotypic peptides for identification of colorectal cancer-specific protein biomarkers; and a mass spectrometry assay-based system for identification and quantification of colorectal cancer-specific protein biomarkers. More particularly, the mass spectrometry-based method comprises steps of: identification of potential protein biomarkers by 10 literature search; detection of differentially expressed proteins and neoantigens for colorectal cancer by data-independent acquisition (DIA) analysis; selection of proteotypic peptides for literature-curated protein biomarkers , differentially expressed proteins and neoantigens from DIA analysis; and optimization of a parallel reaction monitoring (PRM) assay with Natural (NAT) and Stable-Isotope- Standard (SIS) peptides proteotypic 15 peptides. The disclosed method enables a minimally- invasive approach to CRC detection and differentiation of CRC from Inflammatory Bowel Diseases (IBD) with a panel of 15 protein biomarkers.
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