MUMBAI, India, Aug. 12 -- Intellectual Property India has published a patent application (202611079467 A) filed by Noida Institute Of Engineering And Technology Niet on June 27, 2026, for Mitochondria-Targeted Nano Co-Amorphous Composition Of Curcumin And Mitoquinone Mesylate And Process For Preparation Thereof.
Inventors include Dr. Sharad Sharma; and Aparna Gupta.
The application for the patent was published on August 07, 2026, under issue no. 32/2026.
Abstract: A mitochondria-targeted nano co-amorphous composition is disclosed, comprising curcumin and mitoquinone mesylate at a molar ratio of 2:1 to 1:2, wherein the said curcumin and mitoquinone mesylate constitute a single-phase amorphous molecular dispersion stabilised by multi-point intermolecular hydrogen bonding involving the enolic hydroxyl of curcumin and the methoxy, quinone carbonyl and methanesulfonate sulfonyl oxygens of mitoquinone mesylate. The composition exhibits a single glass transition temperature in the range of 95 to 130 degrees Celsius, broad amorphous halos in powder X-ray diffraction, at least five-fold enhanced equilibrium aqueous solubility of curcumin, suppression of recrystallisation under ICH Q1A(R2) long-term and accelerated stress, multi-fold enhancement of oral bioavailability in rat pharmacokinetic studies, mitochondrial accumulation of co-amorphised curcumin, and a favourable therapeutic window. A solvent-based process comprising joint dissolution, vacuum solvent evaporation, vacuum d
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