MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202621064930 A) filed by Shubham A. Mehta; Iti K. Patel; and Dr. Gautam M. Patel on May 22, 2026, for Microwave-Assisted: A Catalyst-Free Buchwald-Hartwig Amination For (+r)-Alkoxy-Based Chloro- Pyrimidines.
Inventors include Shubham A. Mehta; Iti K. Patel; and Dr. Gautam M. Patel.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention discloses a catalyst-free and microwave-assisted amination process for the synthesis of biologically active heterocyclic compounds. The process involves reacting an electron-rich alkoxy-substituted chloro-pyrimidine with a secondary amine in the presence of N,N-diisopropylethylamine (DIPEA) and PEG-400 solvent. The reaction mixture (100, 200, 300) is subjected to microwave irradiation at 110 °C for a compressed duration of 8 to 30 minutes (101, 201, 301). The process entirely eliminates the requirement for transition-metal catalysts, specialized ligands, and inert atmospheric conditions. Following reaction completion and cooling (102, 202, 302), the product is extracted and purified via recrystallization in isopropyl alcohol (103-106, 203-206, 303-306) to afford highly purified aminated compounds. The methodology offers a sustainable, cost-effective, and rapid synthetic platform for pharmaceutical synthesis.
Disclaimer: Curated by HT Syndication.
