MUMBAI, India, Sept. 22 -- Intellectual Property India has published a patent application (202621092127 A) filed by Sardar Vallabhbhai National Institute Of Technology, Surat on July 29, 2026, for Microwave-Assisted N-Acetylation Of Aromatic Amines.
Inventors include Dhaduk, Yash Nileshbhai; Pethani, Maulik Rajeshbhai; Dave, Shreeya Pareshbhai; and Togati, Naveen.
The application for the patent was published on September 18, 2026, under issue no. 38/2026.
Abstract: The present invention relates to a microwave-assisted method for N-acetylation of aromatic amines. The method comprises combining an aromatic amine substrate with copper acetate and azobisisobutyronitrile (AIBN) in 1,2-dichloroethane (DCE) solvent, wherein the copper acetate serves as both the acetylating reagent and catalyst. The reaction mixture is subjected to microwave irradiation to produce a target aromatic amide via a radical pathway. The resulting product is diluted with ethyl acetate and isolated by column chromatography. The method successfully acetylates a diverse range of aromatic amine substrates, including halogen-substituted amines, disubstituted and sterically hindered amines, and heteroaromatic amines such as 2-aminobenzothiazole, 3-aminoquinoline, and 8-aminoquinoline. The protocol provides a simple, economical, and environmentally friendly approach for aromatic amide synthesis without requiring hazardous reagents, inert atmospheres, or complex catalytic systems. (Fig.1)
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