MUMBAI, India, June 26 -- Intellectual Property India has published a patent application (202617034052 A) filed by Taro Pharmaceutical Industries Ltd. on March 20, 2026, for Methods Of Preparing Tapinarof And Related Compounds.
Inventors include Sigal, Adi; Pizem, Hillel; Khamidulina, Asiya; and Avramoff, Avi.
The application for the patent was published on June 19, 2026, under issue no. 25/2026.
Abstract: The present disclosure provides a process for the preparation of 3,5-Dihydroxy-4-isopropyl-trans-stilbene [Tapinarof] and related compounds. Aryl hydrocarbon receptor (AHR) agonists are a novel class of drugs for topical treatment of plaque psoriasis in adults. AHR agonists are believed to inhibiting the release of proinflammatory proteins (cytokines) and downregulating inflammation. 3,5-Dihydroxy-4-isopropyl-trans-stilbene, also known as (E)-2-isopropyl-5-styrylbenzene-1,3- diol or Tapinarof, is a naturally occurring compound found in bacterial symbionts of nematodes.
Disclaimer: Curated by HT Syndication.
