MUMBAI, India, June 19 -- Intellectual Property India has published a patent application (202647067570 A) filed by Regeneron Pharmaceuticals, Inc. on May 29, 2026, for Methods For Reducing Lipase Activity Using Stress.
Inventors include Tang, Xiaolin; and Breydo, Leonid.
The application for the patent was published on June 05, 2026, under issue no. 23/2026.
Abstract: Pharmaceutical formulations comprising an antibody that specifically binds to human interleukin-4 receptor alpha (hIL-4Ra) are provided. The formulations may contain, in addition to an anti-IL-4Ra antibody, one or more buffers, at least one amino acid, at least one sugar, and a surfactant. Methods for producing pharmaceutical formulations with reduced lipase activity are also provided, which may include subjecting a drug substance to agitation stress, heat stress, and additional ion exchange or size exclusion chromatography. In one aspect, the pharmaceutical formulations do not have appreciable subvisible particle formation in the presence of lipase, and exhibit a substantial degree of antibody stability during storage and after being subjected to thermal and other physical stresses.
Disclaimer: Curated by HT Syndication.
