MUMBAI, India, Sept. 14 -- Intellectual Property India has published a patent application (202617065710 A) filed by The Trustees Of The University Of Pennsylvania on May 25, 2026, for Methods And Compositions Comprising A Type I Interferon (ifn1) Inhibitor.
Inventors include Ghassemi, Saba; and Durgin, Joseph.
The application for the patent was published on September 11, 2026, under issue no. 37/2026.
Abstract: The present disclosure provides a method of preparing a population of immune effector cells that express a therapeutic protein or RNA molecule, such as an exogenous receptor, the method comprising contacting a population of immune effector cells with a type I interferon (IFN1) inhibitor. The present disclosure further provides a pharmaceutical composition and methods of treating a condition or disease in a subject in need thereof comprising administering the population of immune effector cells produced by the method disclosed herein. The present disclosure further provides a viral vector comprising (a) a first nucleotide sequence encoding a therapeutic protein or RNA molecule, such as an exogenous receptor, wherein the exogenous receptor comprises a chimeric antigen receptor (CAR), a chimeric autoantibody receptor (CAAR), or a T cell receptor (TCR); and (b) a second nucleotide sequence encoding a type I interferon (IFN1) inhibitor.
Disclaimer: Curated by HT Syndication.
