MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202411104542 A) filed by Lingaya'S Vidyapeeth on December 30, 2024, for Method For Synthesizing 1,3,4-Trisubstituted Pyrazole Derivatives And 2-Amino-1,3,4-Thiadiazoles.
Inventors include Dr. Radhe Shyam; Dr. Rizwan Arif; Dr. Konica Sharma; Dr. Manoj K Malik; Ar. Aditi Arora; Dr. Mortha Chinna Rao; Mr. Bhavik Kuchipudi; Mr. Viraj Gadde; Dr. Rk Deb; Nitish Kumar Singh; R. Muthulakshmi; Yukti Sharma; Divya Negi; Dr. Deepak Kumar Bhalla; and Dr. Mamta Bishnoi.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: ABSTRACT METHOD FOR SYNTHESIZING 1,3,4-TRISUBSTITUTED PYRAZOLE DERIVATIVES AND 2-AMINO-1,3,4-THIADIAZOLES Disclosed herein a method for synthesizing 1,3,4-trisubstituted pyrazole derivatives (100), the method comprises providing 1,3-disubstituted-4-(alkyl/cycloalkylthio)-1H-pyrazole as a starting material. The method further comprising treating the starting material with magnesium bis(monoperoxyphthalate)hexahydrate (MMPP) under mild experimental conditions. Further, oxidizing the alkyl/cycloalkylthio group to form 4-(alkyl/cycloalkylsulfonyl)-1,3-disubstituted pyrazoles, wherein the reaction is carried out at a temperature range of 20°C to 40°C, reducing the generation of chemical waste. FIG.1
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