MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202541041083 A) filed by Indian Institute Of Technology Tirupati on April 29, 2025, for Method For Preparing Hindered And Complex Ethers.
Inventors include Dr Someswara Rao Sanapala; and Sumit Pareek.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: ABSTRACT The present invention provides an efficient and general method for the reductive etherification of carbonyl compounds with alcohols using chlorodimethylsilane (CDMS) in the presence of a commercially available thiourea organocatalyst. This method enables the selective formation of ether bonds across a wide range of alcohols, including primary, secondary, and tertiary alcohols, while tolerating various functional groups such as esters, halides, olefins, alkynes, nitro, cyano, trimethylsilyl, amides, and carbamates. Utilizing chloride anion binding catalysis, the thiourea catalyst enhances oxocarbenium ion electrophilicity, facilitating efficient hydride transfer from CDMS. The method is applicable to the late-stage functionalization of complex molecules, including natural products like steroids, terpenoids, peptides, and carbohydrates, enabling drug modification. Notably, the hydroxyl group in Ritonavir was selectively alkylated to generate novel derivatives. This robust and scalable approach provides a valuable tool for medicinal and synthetic chemistry applications.
Disclaimer: Curated by HT Syndication.
