MUMBAI, India, June 19 -- Intellectual Property India has published a patent application (202637064707 A) filed by Jiangsu Carephar Pharmaceutical Co. , Ltd. on May 22, 2026, for Method For Preparing 1-[5-(2-Fluorophenyl)-1-{[3-(3-Methoxypropoxy)phenyl]sulfonyl}-1h-Pyrrol-3- Yl]-N-Methylmethylamine And Hydrochloride Thereof.
Inventors include Qin, Yinlin; Su, Mei; and Wang, Zhiqiang.
The application for the patent was published on June 05, 2026, under issue no. 23/2026.
Abstract: The present invention provides a method for preparing 1-[5-(2-fluorophenyl)-1-{[3-(3-methoxypropoxy)phenyl]sulfonyl}-1H-pyrrol-3-yl]-N-methylmethylamine and a hydrochloride thereof. In the preparation method, a treatment method after the preparation of 3-(3-methoxypropoxy)benzenesulfonyl chloride (H2) is optimized, and the purity of a sodium sulfonate salt formed after impurity removal is high. Furthermore, by means of a chlorination reaction, 3-(3-methoxypropoxy)benzenesulfonyl chloride (H2) having high purity and stable quality can be obtained. In addition, under the action of an alkali, by adding a small amount of a catalyst, a relatively high reaction conversion rate can be achieved to prepare 5-(2-fluorophenyl)-1-{[3-(3-methoxypropoxy)phenyl]sulfonyl}-1H-pyrrole-3-formaldehyde (H3). The 1-[5-(2- fluorophenyl)-1-{[3-(3-methoxypropoxy)phenyl]sulfonyl}-1H-pyrrol-3-yl]-N-methylmethylamine and the hydrochloride thereof as prepared by the method have a low impurity content and a high yield and is suitable for industrial production.
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