MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202521015325 A) filed by Rungta International Skills University; Rungta College Of Engineering & Technology; and Rungta College Of Pharmaceutical Sciences And Research on February 22, 2025, for Method For Formulating Eutectic Mixture Of Quetiapine With Fatty Acids For Enhanced Bioavailability In Schizophrenia Treatment.
Inventors include Rinkee Verma; Chanchal Deep Kaur; Vijendra Kumar Suryawanshi; Ritika Singh; Divya Sahu; Sandeep Kumar Sonkar; and Anshita Gupta Soni.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: Method for Formulating Eutectic Mixture of Quetiapine with Fatty Acids for Enhanced Bioavailability in Schizophrenia Treatment This invention describes a method of preparation of Quetiapine . It is an antipsychotic drug belonging dibenzodiazepine derivative for treatment of schizophrenia. However, the low bioavailability relates to its low water permeability limits used in oral dosage form. Therefore, to improve the bioavailability of quetiapine of two eutecticsystem of quetiapine (QUE) with fatty acids (myristic acid (MA), palmitic acid (PA)) are used. The binary phase is constructed using differential scanning calorimetry (DSC) data ofmixture prepared from . to . molar ratios of quetiapine with myristic acid and palmitic acid. Binary eutectic mixtures are prepared by physical mixture method. The eutectic mixtureis further characterized by DSC and X- ray diffraction (XRD). Phase diagram intended to improve bioavailability andpermeability of quetiapine. The melting point of QUE-PA, QUE-MA pure drug QUE mixture with varying composition proportions are determined and analyzed by drawing the phase diagram to determined eutectic point and corresponding mixture proportion.
Disclaimer: Curated by HT Syndication.
