MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202617092533 A) filed by Vividion Therapeutics, Inc. on July 30, 2026, for Method For Catalytically Synthesizing Single Chiral 2-Aryl-Substituted Nitrogen Heterocyclic Derivative By Means Of Imine Reductase, And Use Thereof.
Inventors include Wang, Yuanxian; Tang, Zhi; Yu, Aiqin; Zhou, Tianchi; Chen, Jian; Bao, Xianjie; He, Xin; and Zhang, Ye.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: A method for catalytically synthesizing a single chiral 2-aryl-substituted nitrogen heterocyclic derivative by means of an imine reductase, and a use thereof. The method comprises: under the catalytic action of an imine reductase, converting a compound represented by formula II into a single chiral compound represented by formula I. In formulas I and II, each R is independently selected from hydrogen, fluorine, chlorine, bromine, C1-C6 alkyl, halogenated C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cyano, nitro, or carboxyl; X is selected from -CH2- or -O-; and n is an integer selected between 0 and 6. The imine reductase is selected from any one of or a combination of at least two of the following amino acid sequences: (1) an amino acid sequence as shown in any one of SEQ ID NOs: 2, 4, 6, 7, or 10; and (2) an amino acid sequence having imine reductase activity and having at least 90% identity to the sequence as shown in any one of SEQ ID NOs: 2, 4, 6, 7, or 10.
Disclaimer: Curated by HT Syndication.
