MUMBAI, India, June 22 -- Intellectual Property India has published a patent application (202511042330 A) filed by Indian Institute Of Technology Kanpur on May 01, 2025, for Membrane-Free Liver-On-A-Chip Device And Method For Fabricating Thereof.
Inventors include Sivakumar, Sri; Verma, Sandeep; Sati, Preeti; and Ali, Rafat.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: MEMBRANE-FREE LIVER-ON-A-CHIP DEVICE AND METHOD FOR FABRICATING THEREOF The present invention discloses a membrane-free microfluidic device (100) comprising: a microfluidic hexagonal chamber (6) equipped with an inlet port (1), an outlet port (2), and a seeding port (3); a hydrogel matrix (9) encapsulated with a suspension of co-culture of hepatocytes and fibroblast, wherein the hydrogel matrix comprises a polymer functionalized with cysteine–glycine– arginine–glycine–aspartate–serine (CGRGDS) peptide; and a monolayer of a non-parenchymal cell (7) adhered on top of the hydrogel matrix. The present invention also discloses a method for fabricating the membrane-free microfluidic device as described herein.
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