MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202531109661 A) filed by Indian Institute Of Technology Guwahati; and Prof. Dr. Subhendu Sekhar Bag on November 11, 2025, for Maleimide-Scaffolded Fluorescent Enediyne-Amino Acid Hybrids For Supercoiled Dna Cleavage, Antibacterial And Anticancer Activity, And Cell Imaging.
Inventors include Prof. Dr. Subhendu Sekhar Bag; and Suravi Paul.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: ABSTRACT MALEIMIDE-SCAFFOLDED FLUORESCENT ENEDIYNE-AMINO ACID HYBRIDS FOR SUPERCOILED DNA CLEAVAGE, ANTIBACTERIAL AND ANTICANCER ACTIVITY, AND CELL IMAGING The invention provides maleimide- scaffolded fluorescent enediyne-amino acid hybrids (GB-FEd-AA) that exhibit supercoiled DNA cleavage, antibacterial and anticancer activities, and cell imaging capabilities. Synthesized from L-serine via Sonogashira coupling, these compounds cyclize at physiological temperatures, generating diradicals for biological activity. They show low IC50 against cancer cells, selectivity over normal cells, and inherent fluorescence for monitoring, addressing limitations of natural enediynes.
Disclaimer: Curated by HT Syndication.
