MUMBAI, India, June 24 -- Intellectual Property India has published a patent application (202647069118 A) filed by Evonik Operations Gmbh on June 02, 2026, for Liquid Formulation Of Rna.
Inventors include Hrlein, Johannes; and Braun, Max.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: The present invention relates to a liquid formulation of RNA comprising: (a) at least one RNA composition comprising at least one isolated molecule of RNA and a silica carrier, and (b) an adjuvant selected from the group consisting of (A), (B) and (C): (A) a polyglycerol ester with a general formula (I) of, Mj Dk Tl wherein, M is [C3H5(OR'')2O1/2], D is [C3H5(OR'')1O2/2], T is [C3H5O3/2], j=1 to 10, preferably 2 to 3, more preferably 2; k=0 to 10, preferably greater than 0 to 5, more preferably 1 to 3; l=0 to 3, preferably 0 to 1, more preferably 0; wherein, the sum total of j+k+l is 1 to 20, preferably 2 to 4, more preferably 3 wherein the radicals R'' are each independently selected from the group consisting of acyl radicals R'-C (= 0) - and H, with the proviso that at least one radical R'' is not equal to H; wherein the radicals R' are each independently selected from the group consisting of monovalent aliphatic, saturated or unsaturated hydrocarbon radicals with 3 to 39, preferably 7 to 21 more preferably with 9 to 17 carbon atoms; (B) polyether-modified siloxanes of formula (II) M1oD1pD'q wherein, M1 is P13SiO1/2, D1 is P12SiO2/2, D' is P1P2SiO2/2, o is 2, p is between 0 and 0.1, q is between 1.0 and 1.15, P1 are independently hydrocarbyl having 1 to 8 carbon atoms, P2 are independently a polyether radical of the formula (III) —P3O[CH2CH2O]m[CH2CH(CH3)O]nP5 where m is from 3.4 to 11.0, n is from 2.5 to 8.0, and with the provisos that m/n is from 1.9 to 2.8, P3 are independently divalent hydrocarbyl radicals having 2 to 8 carbon atoms, P5 is hydrogen; and (C) organomodified polysiloxane of formula (IV) where a+b+c+d+2 = 20 to 210, a is 15 to 205, b is 1 to 12, c is 1 to 12, d is 1 to 12, the R radicals are each independently identical or different, aliphatic or aromatic hydrocarbyl radicals having 1 to 10 carbon atoms, the R4 radicals are each independently identical or different R, R1, R2 or R3 radicals, the R1, R2 and R3 radicals are each independently different polyether radicals of general formula (V) where e is 3 to 11, f is 6 to 30, g is 0 to 15, h is 0 to 5, i is 0 to 5, and R5 are independently the same or different and are each a methyl, acetyl or hydrogen radical.
Disclaimer: Curated by HT Syndication.
