MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202641123499 A) filed by Ramakrishna Garlapati; Anusha Kota; Dr. Pratyusha Annapragada; Dr. Indira Priyadarshini G; Dr. Mounika V; Sk Sarmas Sri; Adilakshmi Ch; Majjari Venkata Padma; Duddu Swarupa Rani; and Yerragopu Nagasurekha on October 15, 2026, for Iot-Driven Real-Time Monitoring Of Skin Permeation Kinetics.
Inventors include Ramakrishna Garlapati; Anusha Kota; Dr. Pratyusha Annapragada; Dr. Indira Priyadarshini G; Dr. Mounika V; Sk Sarmas Sri; Adilakshmi Ch; Majjari Venkata Padma; Duddu Swarupa Rani; and Yerragopu Nagasurekha.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to an Internet of Things (IoT)-enabled apparatus for assessing the penetration of an active ingredient from a topical formulation into skin using depth-resolved confocal Raman spectroscopy. The apparatus comprises a confocal Raman probe , an objective and axial actuator, a collection acceptance selector , a surface localization unit , a processor , and a communication interface . The collection acceptance selector selectively establishes first and second optical collection acceptance states having different calibrated axial response characteristics. The surface localization unit identifies a skin interface and establishes a reference coordinate for registering focal positions relative to the skin surface. At each selected focal depth, the confocal Raman probe acquires paired Raman observations under the respective collection acceptance states. Exterior Raman observations are additionally acquired or utilized to characterize a superficial spectral contribution associated with formulation residue remaining on the skin surface. The processor jointly fits the paired observations using calibrated response characteristics to estimate a shared subsurface active ingredient profile while separately accounting for the superficial formulation contribution and other relevant spectral background components. A calibration-based validation module evaluates compartment distinguishability, model residuals, measurement uncertainty, signal quality, and compliance with a validated analytical range. When predetermined acceptance criteria are not satisfied, the apparatus initiates reacquisition, performs an authorized corrective measurement procedure, or designates the measurement record as invalid. Upon successful validation, the processor generates a qualified relative penetration profile or a concentration profile supported by an applicable quantitative calibration. The communication interface transmits the resulting assessment together with uncertainty estimates, measurement validity status, focal-depth information, and a calibration identifier to an external computing device or connected data-management platform. The apparatus facilitates traceable, quality-controlled assessment of topical formulations and depth-dependent active ingredient distribution in ex vivo skin penetration studies.
Disclaimer: Curated by HT Syndication.
