MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202647084639 A) filed by University Of Tennessee Research; and Board Of Trustees Of Southern Illinois on July 10, 2026, for Improved Globin And Other Lentiviral Vectors For Gene Therapy.
Inventors include Park, Frank; and Wilber, Andrew.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present subject matter relates to recombinant lentiviral transfer plasmids for producing lentiviral vectors with increased vector titer and performance. These transfer plasmids are constructed so that a central polypurine tract (cPPT) is centered between the lentiviral LTRs and include a 6x stop codon sequence block downstream of the 3' LTR. When the transfer plasmids comprise a globin expression cassette, the lentiviral vectors produced therefrom are useful for treating hemoglobinopathies by gene therapy. Transduced cells, pharmaceutical compositions and methods of treating or ameliorating hemoglobinopathies with these lentiviral vectors are also provided. Additional transfer plasmids, cells, and compositions are provided that are useful for delivering any gene of interest to a cell, as well as plasmids for production of lentiviral vectors for treating other erythroid-specific diseases or disorders such as anemia and cancer.
Disclaimer: Curated by HT Syndication.
