MUMBAI, India, Aug. 24 -- Intellectual Property India has published a patent application (202517072573 A) filed by Obschestvo S Ogranichennoi Otvetstvennostiu Mnt on July 30, 2025, for Hybrid Biomatrix And Method For Producing Same.
Inventors include Chaschin, Ivan Sergeevich; Perepelkin, Evgeny Igorevich; Britikov, Dmitrii Viacheslavovich; Tarasov, Artem Vladimirovich; and Chaschin, Dmitrii Sergeevich.
The application for the patent was published on August 21, 2026, under issue no. 34/2026.
Abstract: The invention relates to the field of biotechnology, medicine and cosmetology, and more particularly to a hybrid matrix for use as a biological graft in the preparation of cardiac prostheses. The technical result of the invention includes improving the surface biocompatibility and the stability and durability of a biological graft which provides an antimicrobial response, and also preventing calcification. A method for producing a hybrid biomatrix comprises the following steps: pre-purifying a base of a biomatrix for 0.75-6 hours in two stages, consisting in the decellularization of xenopericardium in a 2-5 wt% water-alcohol solution of Tween-80, saturated with CO2, at a temperature of 20-400°C and a pressure of 10-30 MPa, and the subsequent decellularization of the xenopericardium in a multi-component system containing a solution based on supercritical CO2 and a 1-1.5 vol% addition of a 2-5 wt% water-alcohol solution of Tween-80, at a temperature of 20-400°C and a pressure of 10-30 MPa; stabilizing the biomatrix base by treatment with a 0.1-0.5 wt% aqueous buffer solution of genipin having a pH of 6.0-7.4 for 3-4 hours; and applying to the pre- purified biomatrix base a coating consisting of an aqueous solution of chitosan nanoparticles with an antimicrobial doping additive in the form of silver or vancomycin nanoparticles in a carbonic acid solution, at a pressure of 20-30 MPa and a temperature of 23-270°C for 1-6 hours.
Disclaimer: Curated by HT Syndication.
