MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202521015313 A) filed by Rungta International Skills University; Rungta College Of Engineering & Technology; and Rungta College Of Pharmaceutical Sciences And Research on February 22, 2025, for Gastroretentive Floating Tablets For Sustained Pantoprazole Sodium Release To Treat Gastroesophageal Reflux Disease.
Inventors include Ranjeeta Kumari; Ajazuddin; Ambika Singh; Ayush Kumar Dewangan; Bhumika Thakur; Karan Kumar Dharme; Akansha Yadav; Devika Sahu; Shashank Kumar Dwivedi; and Ayushi Prajapati.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: Gastroretentive Floating Tablets for Sustained Pantoprazole Sodium Release to Treat Gastroesophageal Reflux Disease This invention describes the development and optimization of gastroretentive floating tablets for the sustained release of pantoprazole sodium, a proton pump inhibitor widely used in the treatment of gastroesophageal reflux disease (GERD) and related gastric conditions. The tablets are designed to achieve prolonged gastric retention and controlled drug release through the integration of hydrophilic polymers, such as hydroxypropyl methylcellulose (HPMC), and gas-generating agents, including sodium bicarbonate and citric acid. Upon contact with gastric fluids, the gas-generating agents produce carbon dioxide, which becomes entrapped within the gel matrix formed by HPMC, ensuring buoyancy and sustained release. The formulation is optimized to exhibit a floating lag time of less than 30 seconds, buoyancy exceeding 10 hours, and a drug release profile achieving 85.09% release within 6 hours. This system offers enhanced bioavailability, reduced dosing frequency, and improved therapeutic outcomes, providing a patient-compliant and scalable solution for advanced drug delivery.
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