MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202621057059 A) filed by Ms. Yashashwi Shrivastav; Ms. Tamanna Borade; Mr. Lalit Dhakar; Dr. Praveen Sharma; Ms. Ankita Bhadoriya; Mr. Sumit Choudhary; Mr. Jeevandeep Mishra; and Dr. Nimita Manocha on May 05, 2026, for Formulation Of Emulsome-Based Gel For Transdermal Management Of Hypertension.
Inventors include Ms. Yashashwi Shrivastav; Ms. Tamanna Borade; Mr. Lalit Dhakar; Dr. Praveen Sharma; Ms. Ankita Bhadoriya; Mr. Sumit Choudhary; Mr. Jeevandeep Mishra; and Dr. Nimita Manocha.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: The present invention relates to an emulsome-based gel formulation for the transdermal delivery of amlodipine besylate for the management of hypertension. Emulsomes comprising a tripalmitin solid lipid core and soya phosphatidylcholine bilayer are prepared by thin film hydration followed by probe sonication and extrusion. The optimized emulsomes exhibit a mean particle size of 276 nanometers, zeta potential of minus 31.6 millivolts, and entrapment efficiency of 82.3 percent. The emulsomes are incorporated into carbopol 934 gel at 1.0 percent w/w to produce a semisolid formulation with pH 6.5 and viscosity of 5920 cP. Ex vivo skin permeation studies demonstrate a transdermal flux enhancement ratio of 3.09 over plain drug gel. The formulation provides controlled release over 24 hours, bypasses first-pass metabolism, and is classified as negligibly irritant, offering a superior alternative to oral antihypertensive therapy.
Disclaimer: Curated by HT Syndication.
