MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202611073931 A) filed by Dr. Jitendra Pal Singh; Dr. L. Anandaraj; Dr. R. Sakunthaladevi; Dr. Monu Bala; Dr. Mohammad Naim; Mr. Amrish Kumar; and Dr. Pooja Agarwal on June 15, 2026, for Fluorescence Imaging Of Rare Earth Ion-Doped Nanoparticles For Targeted Cancer Therapy And Biomedical Applications.
Inventors include Dr. Jitendra Pal Singh; Dr. L. Anandaraj; Dr. R. Sakunthaladevi; Dr. Monu Bala; Dr. Mohammad Naim; Mr. Amrish Kumar; and Dr. Pooja Agarwal.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: The present invention provides a multifunctional rare earth ion-doped nanoparticle composition for fluorescence imaging in the second near-infrared window (1000 to 1700 nm) and targeted cancer therapy. The nanoparticle comprises a crystalline host matrix selected from NaYF4, KNdLiF, NaGdF4 or CeO2, doped with trivalent lanthanide ions such as Nd3+, Yb3+, Er3+ or Tm3+, with an inert or active shell layer for enhanced luminescence, a biocompatible polymeric coating for aqueous dispersibility, and surface-conjugated tumor-targeting ligands such as folic acid or antibodies. The nanoparticle exhibits tunable up-conversion and down-conversion emission, enables deep-tissue NIR-II imaging with tumor-to-background ratio exceeding ten, supports photodynamic therapy via reactive oxygen species generation, and provides stimuli-responsive drug release. The platform integrates diagnostic imaging, magnetic targeting and therapeutic action in a single nanoparticle architecture for advanced cancer theranostics.
Disclaimer: Curated by HT Syndication.
