MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202641091105 A) filed by Vedicmolecule Private Limited on July 27, 2026, for First In Class Gut Barrier Repair Peptide For Management Of Hyperpermeability - Driven Inflammatory Bowel Diseases.
Inventor includes Ramalaxma Reddy Kandimalla.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: The present invention relates to the field of peptide therapeutics and, more particularly, to novel therapeutic peptides capable of restoring intestinal epithelial barrier integrity through modulation of Zonulin-mediated tight junction dysfunction. The invention provides peptides comprising amino acid sequences selected from SEQ ID NOs: 1–15, pharmaceutical compositions comprising the peptides, methods of preparing the peptides using Fmoc-based solid-phase peptide synthesis, and methods of treating disorders associated with intestinal hyperpermeability. The disclosed peptides exhibit high-affinity binding to Zonulin, restore epithelial barrier function, reduce paracellular permeability, and promote tight junction integrity. The peptides are useful in the prevention and treatment of intestinal barrier disorders including inflammatory bowel disease, Crohn's disease, ulcerative colitis, and other diseases associated with epithelial barrier dysfunction.
Disclaimer: Curated by HT Syndication.
