Intellectual Property India Publishes Patent Application for Fabrication Of Selenium Doped Chitosan Scaffolds For Tissue And Bone Engineering Applications

MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202541025176 A) filed by Kamalesh Rengaganathan; Guru Pranatharthiharan Guru Prabhu; Keelstu Saravanan; and Vaidhyanathan Baskaran on March 20, 2025, for Fabrication Of Selenium Doped Chitosan Scaffolds For Tissue And Bone Engineering Applications.

Inventors include Kamalesh Rengaganathan; Guru Pranatharthiharan Guru Prabhu; Keelstu Saravanan; and Vaidhyanathan Baskaran.

The application for the patent was published on September 25, 2026, under issue no. 39/2026.

Abstract: ABSTRACT OF THE INVENTION: Bone tissue engineering requires advanced biomaterials that provide structural support, promote psteogenesis, and enhance vascularization while preventing infections. This invention presents a novel felenium-doped chitosan scaffold, designed for enhanced bone regeneration by integrating the osteogenic, antimicrobial, and antioxidant properties of selenium nanoparticles (SeNPs) with the biocompatibility and ~iodegradability of chitosan. Selenium nanoparticles are uniformly dispersed within the chitosan matrix usmg an optimized fine dispersion protocol, ensuring controlled and sustained selenium release for prolonged bioactivity. The caffold fabrication process, utilizing freeze-drying techniques, produces an interconnected porous structure (I 00-300 ~un range), facilitating mesenchymal stem cell (MSC) adhesion, proliferation, and differentiation. The activation of BMP/Smad and Wnt/J3-catenin pathways enhances osteoblast differentiation and hydroxyapatite mineralization, while selenium's antioxidant properties reduce Reactive Oxygen Species (ROS) and inflammation. Additionally,· SeNPs exhibit broad-spectrum ~ntimicrobial activity, 1ireventing post-surgical infections. Cross-linking with glutaraldehyde or genipin optimizes mechanical stability and biodegradability, ensuring gradual degradation synchronized with new bone formation. Preliminary studies confirm superior mechanical strength, bi!JCOmpatibility, and osteogenic differentiation, making this elcnium-dopcd chitosan scaffold a breakthrough biomaterial for bone tissue engineering and regenerative medicine applications.

Disclaimer: Curated by HT Syndication.