MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202617098207 A) filed by Universiteit Gent on August 13, 2026, for Enhanced Self-Amplifying Or Trans-Amplifying Rna.
Inventors include Vervaeke, Pieter; Sanders, Niek; and Combes, Francis.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: The invention concerns a self-amplifying ribonucleic acid (saRNA) or trans-amplifying ribonucleic acid (taRNA) comprising: an alphavirus genomic 5' untranslated region (5'UTR) or mutant thereof; a nucleic acid sequence encoding alphavirus nonstructural proteins nsP1-4 or mutant thereof; an alphavirus sub-genomic promoter or mutant thereof; and (i) an open reading frame sequence encoding a protein of interest or (ii) a non-coding RNA of interest, wherein the alphavirus genomic 5'UTR or mutant thereof comprises one or more polynucleotide inserts downstream of a nucleotide at position -16, wherein the last nucleotide of the genomic 5' UTR is position - 1, and wherein the length of the combined polynucleotide inserts is at least 5 nucleotides.
Disclaimer: Curated by HT Syndication.
