MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202621078519 A) filed by Ansicht Voneden India on June 25, 2026, for Engineered Exosomal Dna Cassettes And Scaffold For Spinal Cord And Axon Regeneration.
Inventor includes Dr. Ajinkya Inamdar.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: ABSTRACT ENGINEERED EXOSOMAL DNA CASSETTES AND SCAFFOLD FOR SPINAL CORD AND AXON REGENERATION The instant disclosure provides a concoction of 51 engineered DNA cassettes (SEQ ID NOs: 1 to 51) for spinal cord and axon regeneration, classified into cytoprotective and oxidative-stress, immune-modulation, pathology-driver silencing, growth-transcription-factor, partial-reprogramming, neurotrophic-ligand, growth-oriented-receptor, guidance, remyelination, pathway-antagonist and molecular-movement modules, the cargo loaded into or displayed upon engineered extracellular vesicles by a multi-pathway sorting-motif architecture. Reversible dCas9-KRAB repressors release the growth brakes PTEN and suppressor-of-cytokine-signalling-3 and de-repress EphA4- mediated guidance; KLF-6, SOX11 and osteopontin drive the regenerative state; Netrin-1 and GAP-43 guide the regrowing axon; a kinesin motor domain (SEQ ID NO: 51) supports anterograde transport; an OLIG2 remyelination module is deferred to a delayed-release fraction following axonal traversal; and each neurotrophic ligand is co-presented with its cognate receptor. The instant disclosure further provides an electrically semi-conductive hydrogel micro-thread scaffold article incorporating the vesicle population along a spatial gradient and a temporally gated delayed-release sequence, and methods of manufacture thereof. [
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