MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202641122776 A) filed by Dr. Muthadi Radhika Reddy; Dr. Abdul Hameed; Dr. M. Sravanthi; Dr. M. Punithavathi; Prof. Dr. Sudhir Kumar Mishra; Dr. M. Parthasarathy; Dr. V. Gowthami; Dr. S. Gnanam; Dr. N. Punitha; and Dr. Subash Chandra Sahu on October 13, 2026, for Development Of A Chitosan–gold Nanocomposite-Based Prodrug Delivery Platform For Gastro- Protective Anti-Inflammatory Treatment.
Inventors include Dr. Muthadi Radhika Reddy; Dr. Abdul Hameed; Dr. M. Sravanthi; Dr. M. Punithavathi; Prof. Dr. Sudhir Kumar Mishra; Dr. M. Parthasarathy; Dr. V. Gowthami; Dr. S. Gnanam; Dr. N. Punitha; and Dr. Subash Chandra Sahu.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: A chitosan–gold nanocomposite-based prodrug delivery platform for gastro-protective anti-inflammatory treatment, a process for its preparation, and a pharmaceutical composition comprising it are disclosed. The platform comprises gold nanoparticles associated with a mucoadhesive, gastro-protective chitosan matrix to form a chitosan–gold nanocomposite, and an anti-inflammatory agent carried thereon as a prodrug, reversibly linked directly or through a cleavable linking group. The linkage is stable under gastric conditions and is cleaved at or beyond a target site, for example at intestinal pH or by an enzyme, so that the active agent is released in a controlled manner beyond the stomach. Carrying the agent in a masked prodrug form avoids the presence of the free irritant agent in the stomach, while the mucoadhesive, gastro-protective chitosan and the biocompatible gold nanoparticles protect the gastric mucosa, so that the platform delivers the anti-inflammatory agent while mitigating the gastric injury conventionally associated with such agents. The gold nanoparticles may be formed in situ by reduction of a gold precursor by the chitosan, and the loading and release profile are controlled by the preparation parameters.
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