MUMBAI, India, Sept. 22 -- Intellectual Property India has published a patent application (202611091615 A) filed by Dr. Vijay Sharma; Dr. Gurvinder Pal Singh; Mr. Maneesh Kumar Singh; Mr. Saurabh Singh; Dr. Jitendra Singh; Ms. Shikha Meena; Mr. Prashant Kumar; Mrs. Pooja Singh; Dr. Amit Kumar; Dr. Pankaj Kumar Shankhdhar; Sumit Kumar; Dr. Navneet Verma; and Dr. Saurabh Sharma on July 28, 2026, for Development And Optimization Of Arginine-Loaded Nutraceutical Nanoparticles Using A Face- Centered Central Composite Design.
Inventors include Dr. Vijay Sharma; Dr. Gurvinder Pal Singh; Mr. Maneesh Kumar Singh; Mr. Saurabh Singh; Dr. Jitendra Singh; Ms. Shikha Meena; Mr. Prashant Kumar; Mrs. Pooja Singh; Dr. Amit Kumar; Dr. Pankaj Kumar Shankhdhar; Sumit Kumar; Dr. Navneet Verma; and Dr. Saurabh Sharma.
The application for the patent was published on September 18, 2026, under issue no. 38/2026.
Abstract: The present invention discloses a statistically optimised nutraceutical nanoparticulate delivery system in which L-arginine is encapsulated within a chitosan- tripolyphosphate polyelectrolyte matrix prepared by ionic gelation. The formulation is developed through a face-centered central composite design that simultaneously varies polymer concentration, cross-linker concentration and arginine loading at three coded levels, and yields quadratic response surface models for particle size, zeta potential and encapsulation efficiency with adjusted coefficients of determination above 0.97. The optimised composition provides nanoparticles of about 240 nanometers, zeta potential of +54 millivolts, encapsulation efficiency of 81 percent and polydispersity index below 0.30. In vitro dissolution demonstrates sustained release of 86 percent over 12 hours, and in vivo studies in rats show a 2.7-fold enhancement in oral bioavailability compared with free L-arginine, together with excellent long-term and accelerated storage stability suitable for commercial nutraceutical use.
Disclaimer: Curated by HT Syndication.
