MUMBAI, India, Oct. 5 -- Intellectual Property India has published a patent application (202611101624 A) filed by Mr Swatantr Bahadur Singh; Dr. E. Thilagam; Puja Joshi; Ms Ekta Rawal; Shikha Raheja; Amit Girdhar; Nippun Sharma; Dinesh Ghorela; Dr. Mukesh Kumar Sharma; and Abhishek Chhibber on August 22, 2026, for Development And Evaluation Of Phytosome Loaded Berberine Transdermal Patch For Management Of Diabetes..
Inventors include Mr Swatantr Bahadur Singh; Dr. E. Thilagam; Puja Joshi; Ms Ekta Rawal; Shikha Raheja; Amit Girdhar; Nippun Sharma; Dinesh Ghorela; Dr. Mukesh Kumar Sharma; and Abhishek Chhibber.
The application for the patent was published on October 02, 2026, under issue no. 40/2026.
Abstract: The present invention relates to a phytosome-loaded berberine transdermal patch for management of diabetes mellitus. The invention comprises berberine or a pharmaceutically acceptable salt thereof associated with at least one phospholipid to form a phytosomal delivery system, wherein the phytosomal berberine is incorporated into a polymeric transdermal matrix comprising one or more film-forming polymers, plasticizers and optionally penetration enhancers. The phytosomal system modifies the physicochemical characteristics of berberine and facilitates interaction with biological membranes, while the polymeric matrix provides controlled and sustained drug release. The transdermal patch is designed to improve skin permeation and systemic delivery of berberine while potentially reducing limitations associated with conventional oral administration. The formulation may be characterized for particle size, polydispersity, zeta potential, physicochemical compatibility, drug content, mechanical properties, in-vitro release, ex-vivo skin permeation, skin retention, stability and pharmacodynamic antidiabetic activity. The invention provides a potentially scalable transdermal delivery platform for improving the pharmaceutical performance of berberine in the management of diabetes mellitus.
Disclaimer: Curated by HT Syndication.
